Using the NewTek TCXD300 is quite straightforward. First, connect it to the correct power supply that comes with it. Once powered on, you can start using it for your live HD production. When handling the device, be careful around the bent chassis floor area to avoid further damage. Although the misaligned ports don't affect functionality, try not to put too much pressure on them when plugging in cables. For maintenance, keep the device in a clean and dry place. Regularly check the power supply for any signs of wear and tear. If you notice any other issues, it's a good idea to contact customer support.